Single-phase composition containing a perfluorinated oil and one or more surfactant(s), useful as an excipient for cosmetic and dermatologic formulations, as well as for biomedical applications

US4942179A · kind A · utility

Assignees

• Eniricerche S.p.A. · IT
• Enichem Synthesis S.p.A. · IT

Inventors

• Enrico Borgarello · Torino, IT
• Filippo M. Carlini · Novara, IT
• Carlo Neri · San Donato Milanese, IT
• Edoardo Platone · San Donato Milanese, IT

Key dates

• Filing date: Jun 14, 1988
• Grant date: Jul 17, 1990
• Expiry date: Jun 14, 2008

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2800/262
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A single-phase, either isotropic or anisotropic formulation is disclosed, which contains perfluorinated oil and one or more surfactant(s), is useful as an excipient for cosmetic and dermatologic formulations and is characterized in that at least one surfactant is selected from those having the following general formula: ##STR1## wherein: R.sub.F is an F--(CF.sub.2 --CF.sub.2).sub.i -- group; PA0 X is a group selected from: ##STR2## --(CH.sub.2 --O).sub.K --; and --(CH.sub.2 --S).sub.K --; wherein R.sup.I is a (C.sub.1 -C.sub.4)-alkyl; PA0 Y is a group selected from: NH.sub.2 (R.sup.II).sub.2 and N(R.sup.II).sub.4 ; wherein R.sup.II is a hydrogen atom, or a group selected from --CH.sub.2 --CH.sub.2 --OH and (C.sub.1 -C.sub.4)-alkyl; PA0 i is an integer comprised within the range of from 3 to 8; PA0 i is zero or 1; PA0 K is 2.l; PA0 l is an integer comprised within the range of from 1 to 10; PA0 m is 1 or 2. Such composition is spontaneously formed when the components are simply placed into contact with one another. In particular, in case of the isotropic form, the composition is a fluid, clear and stable composition, with particle size smaller than 400 .ANG., containing: PA0 (a) fro…