Supramolecular surfactants: amphiphilic polymers designed to disrupt lipid membranes
US4943624A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Oct 28, 1988 |
| Grant date | Jul 24, 1990 |
| Priority date | — |
| Expiry date | Oct 28, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC11D1/008
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An amphiphilic polymer, having the monomer unit structure A, B, C or D: ##STR1## wherein R is at least one H and C.sub.1-6 alkyl, k=1-4, m=4-30, n=2-50 and x=2-500. ##STR2## wherein p and q are, independently, 0-22, and the sum of p and q is 4-22; ##STR3## wherein r and s are, independently, 0-22, and the sum of r and s is in the range 2-44, Ar is a divalent aromatic radical; and compounds in which the ester group in compounds A, B, C and D is replaced by an amide, urea, urethane, ether or carbonate. These compounds are useful for disrupting lipid membranes, as surfactants and dispersing agents and in the treatment of viral, bacterial and fungal diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.