Certain pyridyl-di-sulfide-alkylenecarbonxylate-ortho-nitro-phenylsulfonic acid esters useful for coupling biological materials
US4943636A · kind A · utility
5Cited by
8References
5Claims
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Key dates
| Filing date | Sep 10, 1987 |
| Grant date | Jul 24, 1990 |
| Priority date | — |
| Expiry date | Sep 10, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/10
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Coupling of biological materials is disclosed via 4-hydroxy-3-nitrobenzene sulfonic acid sodium salt (HNSA) esters. The novel activated esters are structured so as to react at one end with an amine group of a selected biological or non-biological material, thereby releasing the spectroscopically monitorable HNSA dianion, and at the other end with, typically, a sulfhydryl group of a second material which may or may not be biological. The esters provide for a cross-linking reaction that may be easily controlled and monitored.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.