EGF/Liposome gel composition and method
US4944948A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 24, 1989 |
| Grant date | Jul 31, 1990 |
| Priority date | — |
| Expiry date | Feb 24, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/127
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A composition and method for treating a wound or surgical incision, by sustained-released delivery of epidermal growth factor (EGF). The composition includes a high-viscosity aqueous dispersion of negatively charged liposomes with liposome-entrapped EGF. The EGF/liposome composition is formed, in one embodiment of the invention, by suspending a lipid mixture typically containing equimolar amounts of neutral and negatively charged phopholipids and cholesterol in a low-conductivity aqueous medium containing EGF and a zwitterionic compound whose isoelectric point is between pH 5.5 and 8.5 to form a gel-like composition. One embodiment of the invention contains EGF entrapped by surface adsorption to the liposomes, for slow release from the composition.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.