Substituted 1-(oxopyrrolidinylalkanoyl)-piperazines useful as nootropics
US4945092A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 19, 1989 |
| Grant date | Jul 31, 1990 |
| Priority date | — |
| Expiry date | Jun 19, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Substituted pyrrolidin-2-ones of the formula ##STR1## wherein R.sub.1 represents a phenyl or naphthyl radical that is unsubstituted or substituted by lower alkyl, lower alkloxy, halogen and/or trifluoromethyl, X.sub.1 represents lower alkylidene, X.sub.2 represents methylene, ethylene or oxoethylene and R.sub.2 represents hydrogen, lower alkyl or a radical of the formula ##STR2## wherein X.sub.4 represents lower alkylidene and R.sub.3 represents hydrogen or a phenyl or a phenyl naphthyl radical that is unsubstituted by lower alkyl, lower alkoxy, halogen and/or trifluoromethyl, and their pharmaceutically acceptable salts, have nootropic properties and can be used as nootropic active ingredients in medicaments. They are prepared, for example, by condensing with one another compounds of the formulae ##STR3## wherein Z.sub.1 represents a group of the formula --X.sub.1 --(.dbd.O)--Z.sub.3 (IIa) and Z.sub.2 represents hydrogen, or Z.sub.1 represents hydrogen and Z.sub.2 represents a group of the formula --C(.dbd.O) --X.sub.1 --Z.sub.4 (IIIa), wherein each of Z.sub.3 and Z.sub.4 represents a removable radical and R.sub.2 ' represnts a radical R.sub.2 or amino-protecting group, or their sa…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.