Process for the preparation of 4-alkoxyalkyl .beta.-carbolines

US4945163A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Andreas Huth · Berlin, DE
• Dieter Rahtz · Berlin, DE
• Ralph Rohde · Berlin, DE
• Ralph Schmiechen · Berlin, DE
• Dieter Seidelmann · Berlin, DE

Key dates

• Filing date: Aug 30, 1988
• Grant date: Jul 31, 1990
• Expiry date: Aug 30, 2008

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process is disclosed for the preparation of 4-alkoxyalkyl .beta.-carboline derivatives of general Formula I ##STR1## wherein R.sup.1 is hydrogen or methyl, PA0 R.sup.2 is an optionally substituted aliphatic hydrocarbon residue, PA0 R.sup.3 is lower alkyl, and PA0 R.sup.A is hydrogen, halogen, COOR.sup.4 or OR.sup.5, R.sup.4 meaning lower alkyl and R.sup.5 meaning hydrogen, lower alkyl, cycloalkyl, or optionally substituted pheny, by reaction of a compound of Formula II in the presence of AgBF.sub.4 with an alcohol of the formula R.sup.2 OH wherein R.sup.2 has the meanings given above.