Patent · US Expired

Method for resolution of racemic thiamphenicol precursors and intermediates therefor

US4945181A · kind A · utility

1Cited by

4References

11Claims

0Family size

Assignee

Boehringer Mannheim GmbH · DE

Inventors

Helmut Dick · Thun, CH
Wolf-Dietrich Gradel · Ludwigshafen am Rhein, DE
Mathias Weber · Adelsheim, DE

Key dates

Filing date	Dec 1, 1986
Grant date	Jul 31, 1990
Priority date	—
Expiry date	Dec 1, 2006

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P31/04
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention provides a process for the preparation of thamphenicol (I) from D,L-threo-1-(p-methylsulphonylphenyl)-2-aminopropane-1, 3-diol hydrochloride (V) and intermediates thereof. The process comprises conversion to a corresponding benzal compound followed by hydrolysis to D,L-threo-aminodiol.HCl and the following steps: ##STR1##

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.