Method of treating pruritus with nalmefene and clonidine
US4946848A · kind A · utility
11Cited by
6References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 21, 1989 |
| Grant date | Aug 7, 1990 |
| Priority date | — |
| Expiry date | Feb 21, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/485
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of treating a mammal suffering from pruritus, whether antigen-induced or disease-induced, comprising orally administering to the subject from about 1 to about 25 mg of the narcotic antagonist nalmefene for an initial period of 1 to 7 days, and gradually increasing the dosage level of nalmefene by increments of 1 to 25 mg per day during successive periods of 1 to 7 days to a maximum of 150 mg per day. Clonidine or clonidine hydrochloride may be administered concomitantly with the nalmefene to alleviate opioid withdrawal symptoms.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.