1.4-dihydropyridines

US4946851A · kind A · utility

Assignee

• Glaxo SpA · IT

Inventors

• Claudio Semeraro · Bresso, IT
• Dino Micheli · Carpi, IT
• Daniele Pieraccioli · Verona, IT
• Giovanni Gaviraghi · Verona, IT
• Alan David Borthwick · London, GB

Key dates

• Filing date: Oct 28, 1988
• Grant date: Aug 7, 1990
• Expiry date: Oct 28, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/90
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds are described of the formula ##STR1## wherein R.sub.1 and R.sub.4 independently represent a C.sub.1-4 alkyl group; PA1 R.sub.2 and R.sub.3 independently represent a C.sub.1-6 straight or branched alkyl chain or alkoxy group; PA1 R.sub.4 represents a C.sub.1-4 alkyl group; PA1 R.sub.5 represents a group CH.dbd.CR.sub.6 R.sub.7 where R.sub.6 is a hydrogen atom or C.sub.1-3 alkyl group and R.sub.7 represents an aryl, pyridyl or cyano group; or R.sub.5 represents the group C.tbd.CR.sub.8 where R.sub.8 is an aryl group. The compounds represented by formula (I) reduce intracellular calcium ion concentration by limiting transmembranal calcium ion influx and thus may be useful for the treatment of cardiovascular disorders such as hypertension.