Purification of ribotoxins and their conjugates
US4946943A · kind A · utility
6Cited by
0References
20Claims
0Family size
Inventor
Key dates
| Filing date | Feb 16, 1988 |
| Grant date | Aug 7, 1990 |
| Priority date | — |
| Expiry date | Feb 16, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention herein is directed to methods using Procion dyes to perform separations of interest in manipulating the NAD.sup.+ -independent ribotoxins. The methods are useful for preparing therapeutic agents contaning these ribotoxins of their A polypeptide components. This separation method has been applied in particular to preparing hybrid toxins containing ricin toxins, both of purifying the resulting products and also for separating the components intended to be used in the preparation of these end products. In addition, a novel ricin isotoxin prepared using the method of the invention is disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.