Ultrasound enhancement of transbuccal drug delivery
US4948587A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 18, 1988 |
| Grant date | Aug 14, 1990 |
| Priority date | — |
| Expiry date | Aug 18, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M37/0092
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method using ultrasound for enhancing and controlling transbuccal permeation of a molecule, including drugs, antigens, vitamins, inorganic and organic compounds, and various combinations of these substances, through the buccal membranes and into the circulatory system. The frequency and intensity of ultrasonic energy which is applied, and the length of time of exposure are determined according to the location and nature of the buccal membrane and the substance to be infused. Levels of the infused molecules in the blood and urine measured over a period of time are initially used to determine under what conditions optimum transfer occurs. In a variation of the method, whereby ultrasound is applied directly to the compound and site where the compound is to be infused through the buccal membranes, the compound can be placed within a delivery device. In one variation, the ultrasound can control release both by direct interaction with the compound and membrane but also with the delivery device. In another variation, the delivery device helps to modulate release and infusion rate. The compound can also be administered in combination with a chemical agent which alters permeability of the…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.