Patent · US Expired

Immobilized antibodies

US4948836A · kind A · utility

7Cited by

5References

16Claims

0Family size

Assignee

Roehm GmbH Chemische Fabrik · DE

Inventors

Beka Solomon · Herzliya, IL
Eran Hadas · Nesher, IL
Gideon Fleminger · Rehovot, IL

Key dates

Filing date	Nov 14, 1988
Grant date	Aug 14, 1990
Priority date	—
Expiry date	Nov 14, 2008

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10S530/816
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Antibodies which are immobilized and covalently bound to a matrix polymer by means of a modification in a carbohydrate region of the antibodies; wherein the binding of the antibodies is effected by condensing at least one aldehyde group in an oxidized carbohydrate region and at least one epoxide function of an epoxy-group-containing matrix polymer, said condensation being conducted in the presence of a bifunctional reagent which has, on one end position of a spacer unit having at least three members, an amino group capable of condensing with the aldehyde group, and which has on the other end position a group which reacts covalently with the epoxide function.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.