Gonadoliberine analogues of high activity
US4948873A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 21, 1986 |
| Grant date | Aug 14, 1990 |
| Priority date | — |
| Expiry date | Oct 21, 2006 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to novel gonadoliberine analogues of formula I EQU Glp-His-Trp-Ser-X-W-Leu-Arg-Pro-Y (I) wherein PA1 X is Phe-, Tyr (3,5-.sup.3 H) or 3,5-dibromo-tyrosyl, PA1 W is Asu or Asp OR, wherein R is alkyl having 1 to 6 carbon atoms or phenyl or phenyl (alkyl having 1 to 4 carbon atoms), which latter two groups may optionally be substituted by nitro or one or more halogen atoms, and PA1 Y is glycinamide, aza-glycinamide or alkylamino having 1 to 4 carbon atoms, and acid-addition salts thereof, processes for preparing the same and pharmaceutical compositions comprising the same. The novel compounds have an influence on the sexual processes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.