Novel polypeptide having an anti-tumor activity and a method of preparation thereof
US4948875A · kind A · utility
26Cited by
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1Claims
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Key dates
| Filing date | Nov 20, 1987 |
| Grant date | Aug 14, 1990 |
| Priority date | — |
| Expiry date | Nov 20, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/70
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed is a human TNF derivative with a reduced tendency to cause adverse side effects that is obtained by replacing the 31st and 32nd arginine residues from the N-terminal of the amino acid sequence of human TNF, which has a potential for causing serious adverse effects, with asparagine residue and threoine residue, respectively, as well as a method of preparing the same utilizing recombinant DNA technology.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.