Inhibition of lactate production by pyruvate adducts
US4950602A · kind A · utility
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11Claims
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Key dates
| Filing date | Feb 20, 1987 |
| Grant date | Aug 21, 1990 |
| Priority date | — |
| Expiry date | Feb 20, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to inhibitors of lactate dehydrogenase that can cross the blood brain barrier and there is described herein the preparation of several analogues of nicotinamide-adenine-dinucleotide (NAD.sup.+) pyruvate adduct, of which 3(-4-(reduced 3-pyridine aldehyde-adenine dinucleotide))-pyruvate (RAP) and similar compounds appear to have a very high affinity for lactate dehydrogenase; one of which (RAP) was shown to strongly inhibit lactate production in rat brain extracts.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.