T cell immunopotentiator

US4950647A · kind A · utility

Assignee

• Nucleic Acid Research Institute · US

Inventors

• Roland K. Robins · Irvine, US
• Brahma S. Sharma · Irvine, US
• Ganapathi R. Revankar · Irvine, US

Key dates

• Filing date: Oct 4, 1988
• Grant date: Aug 21, 1990
• Expiry date: Oct 4, 2008

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/70
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

##STR1## 6-Amino-1-(2-deoxy-.alpha.D-erythro-pentofuranosyl)imidazo [4,5-C]pyridin-4-one (also know as .alpha.-2'-deoxy-3-deazaguanosine) is non mitogenic to human peripheral blood lymphocytes; however, it displays a potent immunoenhancing activity on human T cells. This compound causes a marked increase in both phytohemagglutinin and Concanavalin A induced proliferation of T cells. When added during allogeneic mixed lymphocyte response, it also potentiates the proliferation of alloreative T cells. The compound shows no potentiating effect on B lymphocytes activated either with Staphylococcus aureus cowan or Pokeweed mitogen, suggesting that it is mainly a T cell function immunopotentiator. The compound overcomes induced immunosuppression and is able to restore depressed proliferative responses of T cells. Further it potentiates the generation of antigen-specific primary cytotoxic T lymphocytes.