16,17-acetalsubstituted androstane-17.beta.-carboxylic acid esters prossessing high binding affinity to the glucocorticosteroid receptor
US4950659A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 25, 1986 |
| Grant date | Aug 21, 1990 |
| Priority date | — |
| Expiry date | Mar 25, 2006 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P29/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention refers to compounds having anti-inflamatory activity characterized by the formula ##STR1## or a stereoisomeric component thereof, in which formula the 1,2-position is saturated or is a double bond PA0 X.sub.1 is selected from hydrogen, fluorine, chlorine and bromine PA0 X.sub.2 is selected from hydrogen, fluorine, chlorine and bromine PA0 R.sub.1 is selected from hydrogen or a straight or branched hydrocarbon chain having 1-4 carbon atoms PA0 R.sub.2 is selected from hydrogen or straight and branched hydrocarbon chains having 1-10 carbon atoms and PA0 R.sub.3 is selected from ##STR2## is O or S R.sub.4 is selected from hydrogen, straight or branched hydrocarbon chains having 1-10 carbon atoms or from phenyl PA0 R.sub.5 is selected from hydrogen or methyl and PA0 R.sub.6 is selected from hydrogen, straight or branched, saturated or unsaturated hydrocarbon chains having 1-10 carbon atoms, an alkyl group substituted by at least one halogen atom, a heterocyclic ring system containing 3-10 atoms in the ring system, ##STR3## (m=0,1,2; n=2,3,4,5,6), phenyl or benzyl groups which are unsubstituted or substituted by one or more alkyl, nitro, carboxy, alkoxy, halogen, cyano, ca…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.