Amine derivatives of anthracycline antibiotics
US4950738A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 5, 1987 |
| Grant date | Aug 21, 1990 |
| Priority date | — |
| Expiry date | Jun 5, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2121/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel antineoplastic amine-containing derivatives and methods for synthesizing such derivatives of anthracycline antibiotics are disclosed. The derivatives are useful to prepare site-selectively attached therapeutic antibody-anthracyline antibiotic conjugates which retain substantial immunospecificity of the unconjugated antibody molecule. Using the conjugates, targeted delivery of the attached antineoplastic amine derivatives of anthracycline antibiotics is achieved in vivo. Such conjugates are thus therapeutically effective against a variety of neoplastic cellular disorders when administered in vivo. Methods for preparing the antibody conjugates and for use of the conjugates in vivo are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.