Method of racemization of optically active tetrahydrofuran-2-carboxylic acid
US4950772A · kind A · utility
2Cited by
0References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 31, 1989 |
| Grant date | Aug 21, 1990 |
| Priority date | — |
| Expiry date | Oct 31, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D307/24
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed is a method of racemization of optically active tetrahydrofuran-2-carboxylic acid. (+)-Tetrahydrofuran-2-carboxylic acid is useful as a side chain intermediate of the antibiotics of penem series, and is prepared by optical resolution of racemic compound. The remaining (+)-isomer should be racemized and reused as the material for further optical resolution. The racemization can be, in accordance with the present invention, carried out by heating the optically active tetrahydrofuran-2-carboxylic acid to a temperature of 100.degree. C. or higher in the presence of a strong base.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.