Feedback controlled release
US4952406A · kind A · utility
37Cited by
3References
25Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 3, 1987 |
| Grant date | Aug 28, 1990 |
| Priority date | — |
| Expiry date | Apr 3, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N11/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A controlled release system using a feedback-responsive controller reversibly changes the pH of the aqueous microenvironment of a biologically active compound sequestered in an aqueous-fluid-penetrable, aqueous-insoluble biocompatible material; the pH change is effected in response to a change in the concentration of the target compound in the aqueous medium surrounding the insoluble material; as a result of the pH change, the aqueous solubility and therefore the release rate of the active compound is reversibly changed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.