Pyridazinone derivatives
US4952571A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 11, 1989 |
| Grant date | Aug 28, 1990 |
| Priority date | — |
| Expiry date | Jul 11, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D409/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to pyridazinone compounds of the general formula I: ##STR1## wherein R.sup.1 represents one to four substituents, which may be the same or different and are selected from H, OH, halogen, NO.sub.2, unsubstituted or C1-C4 alkyl substituted amino, C1-C4 alkyl, C1-C4 halogen substituted alkyl, O--ALK--NR.sup.4 R.sup.5, C1-C4 alkoxy, whereby two substituents taken together may also represent a methylenedioxy group; PA1 R.sup.2 and R.sup.3 represent independently H or C1-C4 alkyl; PA1 R.sup.4 and R.sup.5 represent independently H or C1-C4 alkyl, or form together with the nitrogen a 5- or 6- membered ring; PA1 X represents S or O; PA1 the dotted line represents an optional bond; and their pharmaceutically acceptable salts. The compounds according to the invention have a cardiotonic, blood platelet aggregation inhibiting, systemic vasodilator, pulmonary vasodilator, and bronchodilator activity, and more particularly they show a very potent increase of the force of the muscular contractions of the heart, reduce afterload on the heart, improve pulmonary blood flow, and improve airways ventilation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.