Solutions of oxaphosphorins having improved stability and process for the preparation thereof

US4952575A · kind A · utility

Assignee

• ASTA Pharma Aktiengesellschaft · DE

Inventors

• Dieter Sauerbier · Altentreptow, DE
• Klaus Molge · Bielefeld, DE
• Werner Weigert · Bielefeld, DE
• Otto Issac · Hanau, DE

Key dates

• Filing date: Feb 6, 1989
• Grant date: Aug 28, 1990
• Expiry date: Feb 6, 2009

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Solutions comprising oxazaphosphorins having the general formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are radicals and at least two of said radicals are 2-chloroethyl and/or 2-mathanesulfonyloxyethyl and the remaining radical is selected from hydrogen, methyl and ethyl; and about 80% to about 100% (v/v) ethanol; wherein the oxazaphosphorin concentration is about 10% to about 70% (w/v); and a process for the preparation thereof.