Patent · US Expired

Intermediates in the preparation of alpha1(((1,1-dimethylethyl) amino) methyl)-4-hydroxy-1,3-benzenedimethanol

US4952729A · kind A · utility

2Cited by

4References

3Claims

0Family size

Assignee

Schering-Plough Corporation · FR

Inventors

Esther Babad · West Orange, US
Nicholas I. Carruthers · Plainfield, US
Martin Steinman · Livingston, US

Key dates

Filing date	Nov 3, 1989
Grant date	Aug 28, 1990
Priority date	—
Expiry date	Nov 3, 2009

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C45/46
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

There is disclosed an improved process for preparing albuterol which comprises reacting a 5-(haloacetyl)-2-hydroxybenzaldehyde with 1,1-dimethylethanamine in an organic solvent and in an inert atmosphere to form 5-[[(1,1-dimethylethyl)amino]acetyl]-2-hydroxybenzaldehyde and reducing the carbonyl functions to the corresponding hydroxy groups to form albuterol.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.