Irradiation of blood products
US4952812A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 2, 1989 |
| Grant date | Aug 28, 1990 |
| Priority date | — |
| Expiry date | May 2, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M2205/053
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A thin film or layer of white blood cells, such as the contaminating white cells in a platelet concentrate, is irradiated with ultraviolet radiation predominately of a wavelength of 280 to 320 nanometers, and preferably at an intensity of 4 to 20 milliwatts per square cm. to provide a total energy exposure of typically 800 to 20,000 millijoules per square cm. of ultraviolet radiation. The white blood cells so produced substantially lose their capability to set off an immune reaction in an alloimmunized patient. The white blood cells may preferably be placed into such film in a flat, flexible bag made of poly(ethylene-vinyl acetate) plastic, with the flat, flexible bag being stretched in a direction normal to the path of ultraviolet radiation. Novel irradiating devices are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.