Pharmaceutical composition for intrarectal administration of a calcitonin and unit dosage forms prepared therefrom
US4954342A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 26, 1988 |
| Grant date | Sep 4, 1990 |
| Priority date | — |
| Expiry date | Sep 26, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P5/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
New compositions containing a calcitonin as the active ingredient are described which are suitable for the intrarectal administration as soft gelatin capsules or microenemas, wherein the active principle, optionally admixed with a stabilizer, is dissolved in a liquid vehicle consisting of: (a) at least 70% by weight of a polyethylene or a polypropylene glycol or a mixture of polyethylene or polypropylene glycols with different molecular weights, having the consistency of a homogeneous fluid at room temperature, and (b) less than 15% by weight of a buffer in a pH range of from 4.5 to 6.5, and optionally (c) less than 15% by weight of an alcohol of 2 to 6 carbon atoms containing two or more hydroxy groups. The new compositions, which do not contain any absorption aid, give calcitonin plasma levels comparable to a conventional intramuscular administration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.