Orally administrable nifedipine solution in a solid light resistant dosage form

US4954346A · kind A · utility

Assignee

• Ciba-Geigy · US

Inventors

• Gregory Sparta · Bound Brook, US
• Christopher L. Pelloni · Newtown, US
• Deborah Winkel · Alva, US

Key dates

• Filing date: Jun 8, 1988
• Grant date: Sep 4, 1990
• Expiry date: Jun 8, 2008

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/44
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A solid dosage form having a fill composition encased in a shell composition; the fill composition comprising PA1 (a) 5-60 mg of nifedipine; PA1 (b) a 5-7 membered cyclic pharmaceutically acceptable ingestible carbonate of the formula ##STR1## where A is an alpha,omega-C.sub.2 -C.sub.4 alkylene which is unsubstituted or substituted by at least one C.sub.1 -C.sub.4 alkyl; and PA1 (c) a pharmaceutically acceptable ingestible surfactant having a total of d ring members and being of the formula ##STR2## wherein B is a C.sub.1-4 -alpha,omega-alkylene; PA2 n is an integer from 0 up to d-1; PA2 m is an integer from 0 up to (d-n-1); PA2 each R is independently H or a C.sub.1-4 alkyl which is unsubstituted or substituted by at least one R'; PA2 each R' is independently a hydroxy which is free, etherified by R.sup.2, or esterified by R.sup.3 ; PA2 each R.sup.2 is a C.sub.2-4 straight or branched oxyalkylene or a poly (C.sub.2-4 straight or branched oxyalkylene), the terminal oxygen of which is bound to hydrogen or R.sup.3 ; and each R.sup.3 is independently an acyl of a C.sub.2-24 alkanoic acid or a C.sub.4-24 alkeneoic acid; provided that there is at least one free hydroxy group, at least o…