Penetrating topical pharmaceutical compositions
US4954487A · kind A · utility
175Cited by
14References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 15, 1989 |
| Grant date | Sep 4, 1990 |
| Priority date | — |
| Expiry date | Feb 15, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A large group of lipophilic, pharmacologically active compounds can be effectively delivered across intact skin by applying them topically in a binary, penetration-enhancing vehicle containing (1) a C.sub.3 -C.sub.4 diol, diol ester, or diol ether and (2) a cell envelope-disordering compound. This vehicle provides surprising enhancement of skin penetration for the pharmacological active, compared to either component alone.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.