Tricyclic benzimidazole compounds, pharmaceutical compositions and methods of use

US4954498A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Alfred Mertens · Schriesheim, DE
• Wolfgang von der Saal · Rosenheim, DE
• Erwin Boehm · Ladenburg, DE
• Klaus Strein · Hemsbach, DE

Key dates

• Filing date: Jan 15, 1988
• Grant date: Sep 4, 1990
• Expiry date: Jan 15, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides tricyclic benzimidazoles of the formula: ##STR1## wherein R.sub.1 is a phenyl radical of the general formula: ##STR2## wherein R.sub.2, R.sub.3 and R.sub.4 can be the same or diferent as in claim 1. For A, B, C and D are understood those compounds where one or two of A, B, C or D are nitrogen. These compounds are useful to inhibit the aggregation of thrombocytes and erythrocytes, lower blood pressure and can increase the power of the heart.