DNA sequences, recombinant DNA molecules and processes for producing lymphocyte function associated antigen-3

US4956281A · kind A · utility

Assignees

• Biogen Inc. · US
• DANA-FARBER CANCER INSTITUTE, INC. · US

Inventors

• Barbara P. Wallner · Cambridge, US
• Timothy A. Springer · Newton, US
• Catherine Hession · Hingham, US
• Richard Tizard · Cambridge, US
• Robert Mattaliano · Newton, US
• Michael L. Dustin · University City, US

Key dates

• Filing date: Jun 3, 1987
• Grant date: Sep 11, 1990
• Expiry date: Jun 3, 2007

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Polypeptides that bind to CD2, the receptor on the surface of T-lymphocytes. Most preferably, the polypeptides bind to CD2 on the surface of T-lymphocytes and inhibit adhesion between T-lymphocytes and target cells. DNA sequences that code on expression in appropriate unicellular hosts for those polypeptides. Methods of making and using those polypeptides in therapy and diagnosis.