Water-soluble L-tyrosine derivatives and a process for preparing L-tyrosine derivatives
US4956489A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 14, 1988 |
| Grant date | Sep 11, 1990 |
| Priority date | — |
| Expiry date | Oct 14, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61Q19/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to the preparation of water-soluble L-tyrosine derivatives having the formula ##STR1## where R.sub.1 is a L-malyl, L-lactyl, L-glutamyl or L-aspartyl group, R.sub.2 is a --OH, --OM, methoxy, ethoxy or amino group and M is an alkaline metal, by enzymatic condensation of an acid selected among L-malic, L-lactic, L-glutamic and L-aspartic acids, with a L-tyrosine derivatives selected among the ethyl and methyl esters and the amide of L-tyrosine. The enzyme is obtained from a culture of Micrococcus casealyticus. The compounds where R.sub.1 is a L-malyl or L-lactyl group are new. Said L-tyrosine derivatives are useful in cosmetic and pharmaceutical compositions, such as tanning and sun compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.