Continuous sonication method for preparing protein encapsulated microbubbles
US4957656A · kind A · utility
252Cited by
7References
6Claims
0Family size
Assignee
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Key dates
| Filing date | Sep 14, 1988 |
| Grant date | Sep 18, 1990 |
| Priority date | — |
| Expiry date | Sep 14, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K49/223
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An ultrasonic imaging agent is produced by a continuous sonication processing of an aqueous solution of heat-denaturable biocompatible protein. The solution is carefully preheated to a temperature of incipient protein denaturation without forming insolubilized protein. A gaseous fluid, preferably air, is added to the solution. In the sonication, the air-containing solution is foamed, increasing the formation and concentration of microbubbles, and the solution is further heated to insolubilize a portion of the protein, thereby encapsulating the microbubbles and forming particulate microspheres.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.