Benzimidazoles, and pharmaceutical preparations containing these compounds

US4957920A · kind A · utility

Assignee

• Heumann Pharma GmbH · DE

Inventors

• Peter Morsdorf · Langenzenn, DE
• Helmut Schickaneder · Eckental, DE
• Rolf Herter · Schwabach, DE
• Volker Pfahlert · Munich, DE
• Heidrun Engler · Cadolzburg, DE
• Kurt H. Ahrens · Nürnberg, DE

Key dates

• Filing date: Mar 15, 1988
• Grant date: Sep 18, 1990
• Expiry date: Mar 15, 2008

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

New benzimidazoles corresponding to the general formula I ##STR1## are described, in which the pyridazinone ring is attached in the 5- or 6- position of the benzimidazole ring and R.sup.1 denotes a hydrogen atom or a straight chained or branched C.sub.1 to C.sub.4 alkyl group, R.sup.2 denotes a hydrogen atom, a straight chained or branched C.sub.1 to C.sub.4 alkyl group, a C.sub.1 to C.sub.4 alkoxy group, a hydroxy group, a halogen atom, an amino group or a nitro group, A denotes a hydrogen atom, a group of the formula ##STR2## wherein R.sup.3 denotes a hydrogen atom, an optionally substituted C.sub.1 to C.sub.4 alkyl group or a C.sub.1 to C.sub.4 alkoxy group and B denotes a cyano group, a benzoyl group or a phenylsulphonyl group, or A denotes a group of the formula ##STR3## in which m has the value of 2 or 3 and n represents an integer from 1 to 6, and the physiologically acceptable salts thereof as well as processes for their preparation and pharmaceutical preparations containing these compounds. These compounds are new, effective, positive inotropic substances which do not act by the mechanism of phosphodiesterase inhibition.