Anti-spasmdoic agents having an acetylenic bond
US4957941A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jan 9, 1990 |
| Grant date | Sep 18, 1990 |
| Priority date | — |
| Expiry date | Jan 9, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D295/084
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A new class of anti-spasmodic compounds having two branch chains is provided. The compounds have the general formula: ##STR1## where Y is H or OH; PA0 j is an integer from 0 to 4; PA0 k is an integer from 0 to 4, and wherein PA0 m is an integer from 1 to 4; PA0 n is an integer from 1 to 4; PA0 p is an integer from 1 to 4; and PA0 X may be nonexistent or may be O, S, NH or CH.sub.2 or salts thereof, but when X is nonexistent the terminal group in which both the n-chain and the p-chain is a methyl group. ##STR2## The reaction was performed under reflux condensation. Following the reaction, which was usually complete within a few hours, the acid chlorides were vacuum distilled and reacted with a thiol compound as described above. The compounds of this invention are anti-muscarinic agents (cholinergic-muscarinic receptor antagonists) which inhibit the actions of acetylcholine on autonomic effectors innervated by postganglionic cholinergic nerves as well as on smooth muscle that lacks cholinergic innervation. Since a major component of parasympathetic control of smooth muscle occurs via muscarinic receptors, these compounds are effective as modifiers of smooth muscle activity. Thiphenam…
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