Anti-human ovarian cancer immunotoxins and methods of use thereof

US4958009A · kind A · utility

Assignee

• Cetus Corporation · US

Inventors

• Michael J. Bjorn · Hercules, US
• David Fitzgerald · Rockville, US
• Arthur E. Frankel · Dallas, US
• Walter J. Laird · Pinole, US
• Ira H. Pastan · Potomac, US
• David B. Ring · Palo Alto, US
• Mark C. Willingham · Summerville, US
• Jeffrey L. Windelhake · Alameda, US

Key dates

• Filing date: Jul 6, 1987
• Grant date: Sep 18, 1990
• Expiry date: Jul 6, 2007

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/864
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Immunotoxins comprising a cytotoxic moiety and monoclonal antibodies which bind to human ovarian cancer tissue having at least one of the following capabilities are claimed: cytotoxic ID.sub.50 of 10 nM or less against human ovarian cancer cells, retardation of human ovarian cancer tumor growth in mammals or extension of survival of a mammal carrying a human ovarian cancer tumor. Antigens to which the monoclonal antibody of the immunotoxin bind are identified and characterize the immunotoxins. Methods of killing human ovarian cancer cells, retarding the growth of human ovarian cancer tumors in mammals or extending the survival of mammals carrying human ovarian cancer tumors are claimed.