Method for production of 3-exomethylenecepham derivatives
US4958018A · kind A · utility
3Cited by
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17Claims
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Inventors
Key dates
| Filing date | May 4, 1989 |
| Grant date | Sep 18, 1990 |
| Priority date | — |
| Expiry date | May 4, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed is a method of producing a 3-exomethylenecepham of the formula ##STR1## wherein R.sup.1 is amino or substituted amino and R.sup.2 is a carboxy-protecting group comprising reacting a cephem of the formula ##STR2## wherein R.sup.1 and R.sup.2 are as defined above and X is halogen with lead metal while maintaining the pH of the reaction system at about 0.1 to 8. The cephem (I) may be reacted with a catalytic amount of lead metal or a lead compound in the presence of a metal having a greater ionization tendency than lead.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.