Ifosfamide-mesna lyophilizate and process for its preparation

US4959215A · kind A · utility

Assignee

• ASTA Pharma Aktiengesellschaft · DE

Inventors

• Dieter Sauerbier · Altentreptow, DE
• Otto Isaac · Hanau, DE
• Wolfgang P. Brade · Usingen, DE

Key dates

• Filing date: Mar 20, 1989
• Grant date: Sep 25, 1990
• Expiry date: Mar 20, 2009

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An ifosfamide-mesna lyophilizate consists substantially of ifosfamide, 0.1-1.0 parts by weight of mesna and 0.1 to 17 parts by weight of hexitol. The product is obtained by freeze drying an aqueous or aqueous-ethanolic solution of ifosfamide and mesna.