Contraceptive methods and delivery systems thereof
US4959216A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Dec 17, 1987 |
| Grant date | Sep 25, 1990 |
| Priority date | — |
| Expiry date | Dec 17, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/0036
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A contraceptive method for living animals (including human beings) can utilize a polyurethane or polyvinylacetate (PVA) disc as an inert carrier for contraceptive preparations, the disc being implanted before intercourse to engage the external os of the cervical canal. Preferred contraceptive preparations include (1) the copper (II) salt of ethylenediamine-tetraacetic acid (EDTACu) and L-L-ascorbic acid; (2) the sialic acid-removing enzyme neuraminidase; and (3) an asialoglycoprotein, such as asialofetuin. Of these preparations, which can be used separately or in any combination, the first two act on the cervical mucus to change it from the open cellular structure found at midcycle of the menstrual period to the closed cellular structure and thus form an impenetrable barrier for spermatozoa. The second and third preparations remove sialic acid from spermatozoa, the presence of which is necessary for successful fertilization.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.