Monoclonal antibody, process for preparing same, reagent for detecting cancer antigen containing the monoclonal antibody and process for preparing same
US4959320A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 8, 1985 |
| Grant date | Sep 25, 1990 |
| Priority date | — |
| Expiry date | Aug 8, 2005 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A monoclonal antibody is described, having a specific reactivity with a cancer-associated antigen selected from pancreas cancer-associated antigen, intestinum crassum cancer-associated antigen and hepatoma-associated antigen and has the following characteristics: PA0 (1) it exists in a blood serum of pancreas cancer, intestinum crassum cancer and hepatoma patients; PA0 (2) it comprises glycoproteins; PA0 (3) it has a molecular weight of about 700,000 to 1,500,000, as measured by gel-filtration and determined by comparison with that of a known protein; PA0 (4) it has a maximum absorption of 2800 nm when dissolved in 0.1 M acetic acid buffer solution (pH 4.5); and PA0 (5) it is released at least in a cultured supernatant medium of establihed cell line of COLO-201, TE-1, TE-2, TE-3, NRC-12, MKN-45 and KATO III. The monoclonal antibody is utilized as a reagent for detecting pancreas cancer, intestinum crassum cancer and hepatoma. A process for preparing the monoclonal antibody and a process for preparing the reagent are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.