Crystal suspensions of insulin derivatives, processes for their preparation and their use
US4959351A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jul 27, 1984 |
| Grant date | Sep 25, 1990 |
| Priority date | — |
| Expiry date | Jul 27, 2004 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a process for the preparation of crystal suspensions of one or more insulin derivatives of the formula I ##STR1## R.sup.1 denotes H or H-Phe, R.sup.30 represents the radical of a neutral L-aminoacid which can be genetically coded and PA1 R.sup.31 represents a physiologically acceptable organic group of basic character with up to 50 carbon atoms, in the build-up of which 0 to 3 .alpha.-aminoacids participate and in which any terminal carboxyl function present can be free, as the ester function, as the amide function, as the lactone or reduced to CH.sub.2 OH, with an isoelectric point between 5.8 and 8.5, which comprises carrying out the crystallization in an aqueous medium close to the isoelectric point of the derivative or derivatives in the presence of an aromatic hydroxy compound, to crystals and crystal suspensions obtained by the process and to the use thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.