Mycophenolic acid derivatives in the treatment of rheumatoid arthritis
US4959387A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 24, 1987 |
| Grant date | Sep 25, 1990 |
| Priority date | — |
| Expiry date | Nov 24, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D307/88
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method of treating rheumatoid arthritis which method comprises administering to a mammal in need of such treatment a therapeutically effective amount of a compound of the formula: ##STR1## and the pharmaceutically acceptable salts thereof, wherein: A is oxygen or sulfur; PA0 R.sup.1 is selected from the group consisting of H, ##STR2## in which Y is oxygen or sulfur: PA0 R.sup.2 is alkyl, haloalkyl or --NR.sup.4 R.sup.5, where R.sup.4 and R.sup.5 are independently H, alkyl, haloalkyl, cycloalkyl, phenyl optionally monosubstituted with halogen, hydroxy, carboxy, chlorocarbonyl, nitro, cyano, phenyl, alkyl, acyl, alkoxycarbonyl, acylamino, dialkylamino or dialkylaminoethoxycarbonyl, phenyl optionally disubstituted with hydroxy, carboxy, nitro or alkyl, or benzyl optionally substituted with dialkylamino; PA0 n is an integer from 0-6; PA0 R.sup.3 is H alkyl or a pharmaceutically acceptable cation; PA0 Q and R are independently H or --CO.sub.2 R.sup.3 ; and Z is selected from the group consisting of ##STR3## in which X is oxygen or sulfur, PA0 R.sup.7 is H, alkyl, alkenyl, cycloalkyl, optionally substituted phenyl, optionally substituted benzyl or a pharmaceutically acceptable cation; …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.