Heteroaryloxy-.beta.-carboline derivatives, their preparation and their use as medicinal agents

US4960777A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Helmut Biere · Berlin, DE
• Andreas Huth · Berlin, DE
• Dieter Rahtz · Berlin, DE
• Ralph Schmiechen · Berlin, DE
• Dieter Seidelmann · Berlin, DE
• David N. Stephens · Berlin, DE
• Mogens Engelstoft
• John Bondo Hansen · Avenue Madeleine, DK

Key dates

• Filing date: Sep 20, 1989
• Grant date: Oct 2, 1990
• Expiry date: Sep 20, 2009

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Heteroaryloxy-.beta.-carboline derivatives of general Formula I ##STR1## wherein R.sup.1 is an optionally substituted heteroaryl residue, PA1 R.sup.2 is hydrogen, lower alkyl or lower alkoxyalkyl, PA1 X is a COOR.sup.3 -group wherein R.sup.3 means H or lower alkyl, or represents a CONR.sup.4 R.sup.5 -group wherein R.sup.4 and R.sup.5 mean respectively hydrogen or lower alkyl, R.sup.4 and R.sup.5 being capable of forming, together with the nitrogen atom, a 5- to 6-membered heterocycle, or means an oxadiazolyl residue of the formula ##STR2## wherein R.sup.6 means hydrogen, lower alkyl or cycloalkyl, are valuable pharmaceuticals.