Piperazines and homopiperazines
US4960883A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 15, 1989 |
| Grant date | Oct 2, 1990 |
| Priority date | — |
| Expiry date | Feb 15, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D295/26
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A propane derivative represented by the following formula ##STR1## wherein R represents a lower alkyl group; one of A and B represents a group of the formula ##STR2## and the other represents a group of the formula ##STR3## in which R.sup.1 and R.sup.2 are identical or different and each represents a hydrogen atom, a lower alkyl group, an aryl group or an aralkyl group, R.sup.3 represents a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aryl group or a substituted or unsubstituted heterocyclic group, and X represents a sulfonyl group or a carbonyl group, and an acid addition salt thereof. The compounds provided by this invention have useful biological activities such as the spasmolytic activity on the vascular smooth muscles and anti-platelet aggregatory activity and are useful as drugs for treating cardiovascular diseases such as angina pectoris, cerebral circulation disorder and thrombosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.