Preparation of 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine compounds
US4960888A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 9, 1989 |
| Grant date | Oct 2, 1990 |
| Priority date | — |
| Expiry date | Mar 9, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/50
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to a new process for preparing 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine of the formula (I), ##STR1## which comprises reacting a pyrimidine derivative of the general formula (II), ##STR2## wherein R.sub.1 stantds for hydrogen or a ##STR3## group, wherein R means a C.sub.1-6 alkyl group or an aryl group optionally substituted by halogen; PA1 R.sub.2 stands for a hydroxyl group or an ##STR4## group, wherein R is as defined above; and PA1 X represents chlorine or bromine or an optionally mono- or polysubstituted arenesulfonyloxy group, with the proviso that R.sub.2 is different from a hydroxyl group when R.sub.1 stands for hydrogen, with piperidine and hydrolyzing, optionally after isolation, the thus-obtained 4-piperidino derivative of the general formula (III), ##STR5## wherein R.sub.1 and R.sub.2 are as defined above.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.