Process for the preparation of pharmaceutical compositions
US4960913A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 5, 1989 |
| Grant date | Oct 2, 1990 |
| Priority date | — |
| Expiry date | May 5, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C233/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to a process for the preparation of tetracycline derivatives of the formula ##STR1## and acid addition salts thereof --wherein R stands for --CH.sub.3 or .dbd.CH.sub.2 --by dehalogenating and hydrogenating chloromethacycline or acid addition salt thereof of the formula ##STR2## or by hydrating methacycline or acid addition salts thereof of the formula ##STR3## by treatment with hydrogen gas in the presence of a noble metal alloy catalyst on carrier and organic solvent which comprises performing, hydrogenating under pressure of 0.1-1.0 MPa with an alloy catalyst consisting of the alloy palladium or platinum and selenium and/or tellurium used at a ratio of 1:0.01-0.5 related to the amount of the starting tetracycline and carrying out, if desired dehalogenation and hydrogenation in one step.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.