Surface modified surgical instruments, devices, implants, contact lenses and the like

US4961954A · kind A · utility

Assignee

• University of Florida Foundation, Incorporated · US

Inventors

• Eugene P. Goldberg · Gainesville, US
• James W. Burns · Watertown, US
• G. Sudesh Kumar · Nagamangala, IN
• David C. Osborn · Manchester, US
• Jeffrey A. Larson · Monrovia, US
• John W. Sheets, Jr. · Fort Worth, US
• Ali Yahiaoui · Roswell, US
• Richard D. Robinson · Ithaca, US

Key dates

• Filing date: Feb 1, 1989
• Grant date: Oct 9, 1990
• Expiry date: Feb 1, 2009

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/31663
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Improved medical devices and instruments prepared by an improved method of producing hydrophilic, gamma irradiation induced polymerized and chemically grafted coatings or plastic surfaces of articles adapted for contacting living tissue, the improvement comprising carrying out the graft polymerization in an aqueous solution under specific combinations of the following conditions: PA1 (1) monomer concentration in the range of from about 0.5% to about 50%, by weight; PA1 (2) total gamma dose in the range of from about 0.01 to less than about 0.50 Mrad; PA1 (3) gamma dose rate in the range of from about 10 to about 2500 rads/min; and PA1 (4) maintaining the molecular weight of the polymer in solution in the range of from about 250,000 to about 5,000,000.