Agent for cerebral protection
US4962107A · kind A · utility
10Cited by
1References
2Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Mar 10, 1989 |
| Grant date | Oct 9, 1990 |
| Priority date | — |
| Expiry date | Mar 10, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D295/185
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the general formula ##STR1## wherein: X is halogen or trifluoromethyl; PA0 R.sub.1 is hydrogen, halogen or trifluoromethyl; PA0 R.sub.2 is hydrogen methyl or hydroxymethyl; PA0 R.sub.3 is hydrogen or lower alkyl; and PA0 Y is methylene, methylene substituted with a lower alkyl or hydroxyl group, sulfinyl, sulfonyl, oxygen or sulfur, exhibit a cerebral protective effect and are applicable to the treatment of cerebral ischaemia and cerebral hypoxia. The compounds may be made by acylating a suitable piperidine or morpholine with the appropriate cinnamoyl chloride, and if necessary oxidizing the reaction product.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.