Ribotoxin conjugates
US4962189A · kind A · utility
6Cited by
1References
4Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Dec 11, 1987 |
| Grant date | Oct 9, 1990 |
| Priority date | — |
| Expiry date | Dec 11, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention herein is directed to methods using Procion dyes to perform separations of interest in manipulating the NAD.sup.+ -independent ribotoxins. The methods are useful for preparing therapeutic agents containing these ribotoxins or their A polypeptide components. This separation method has been applied in particular to preparing hybrid toxins containing ricin toxins, both for purifying the resulting products and also for separating the components intended to be used in the preparation of these end products. In addition, a novel ricin isotoxin prepared using the method of the invention is disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.