Certain pyridinoylamino-indolin-2-one derivatives

US4963686A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Jens-Peter Holck · Mannheim, DE
• Alfred Mertens · Schriesheim, DE
• Wolfgang Kampe
• Bernd Muller-Beckmann · Bamberg, DE
• Gisbert Sponer · Hemsbach, DE
• Klaus Strein · Hemsbach, DE

Key dates

• Filing date: Jul 5, 1988
• Grant date: Oct 16, 1990
• Expiry date: Jul 5, 2008

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The new pyrrolobenzimidazoles according to the present invention are compounds of the general formula: ##STR1## wherein R.sub.1 is a hydrogen atom or an alkyl, alkenyl or cycloalkyl radical, R.sub.2 is a hydrogen atom, an alkyl or alkenyl radical or a cyano group or a carbonyl group substituted by a hydroxyl or hydrazino group or by an alkyl, alkoxy, amino, alkylamino or dialkylamino group or together with R.sub.1 represents a cycloalkylene radical or R.sub.1 and R.sub.2 together form an alkylidene or cycloalkylidene radical, X is a valency bond, a C.sub.1 -C.sub.4 alkylene radical or a vinylene radical, T is an oxygen or sulphur atom and Py is a 2-, 3- or 4-pyridyl radical which optionally carries an oxygen atom on the ring heteroatom and/or can be substituted one or more times by alkyl, alkoxy, hydroxyl, cyano or nitro, as well as by halogen; the tautomers thereof and the physiologically acceptable salts thereof with inorganic and organic acids.