Oxidized viruses or viral antigens and utilization for diagnostic prophylactic and/or therapeutic applications
US4965069A · kind A · utility
Inventors
Key dates
| Filing date | May 20, 1987 |
| Grant date | Oct 23, 1990 |
| Priority date | — |
| Expiry date | May 20, 2007 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/82
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel and improved methods for diagnosis, prognosis, prophylaxis and therapy of viral infections are described. The novel methods employ a virus, viral antigen or fragment thereof in which "perturbation" of an oligosaccharide moiety renders the virus, viral antigen or fragment thereof more specifically recognizable or reactive with neutralizing antibody. As described, "perturbation" of an oligosaccharide moiety encompasses a variety of modifications such has one that (1) alters the chemical or physical structure of a carbohydrate residue that is naturally present; (2) that removes, wholly or in part, a carbohydrate residue; and/or (3) that prevents or alters addition of a carbohydrate residue. A variety of different methods for oligosaccharide "perturbation" are also described. In particular, the carbohydrate residue is altered by an oxidizing agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.