Process for the production of 4,5,6,7-tetrahydrothieno-[3,2-C]-pyridines
US4965359A · kind A · utility
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Key dates
| Filing date | Sep 20, 1989 |
| Grant date | Oct 23, 1990 |
| Priority date | — |
| Expiry date | Sep 20, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D211/74
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the production of 4,5,6,7-tetrahydrothieno-[3,2-c]-pyridines of the formula: ##STR1## Thus, in the case of a 4-oxo-3-piperidine-3-carboxylic acid ester of the formula: ##STR2## an allyl group is introduced in the 3 position, the ester function in the 3 position is removed, the resultant compound of the formula: ##STR3## is ionized, reduced to the corresponding aldehyde of the formula: ##STR4## and with H.sub.2 S/HCl in the presence of a metal halide is cyclized to the end product. The synthesized compounds have antithrombotic action.
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